Mar 27, 2020 accidental ingestion of meperidine, especially by children, can result in a fatal overdose of meperidine. Sep 19, 2018 concomitant use of demerol tablets or oral solution with a cyp3a4 inhibitor, such as macrolide antibiotics e. Tell your doctor if you are pregnant or plan to become pregnant. Meperidine is an opioid agonist and therefore has abuse potential and risk of fatal overdose from respiratory failure. Oxycontin oxycodone hydrochloride extendedrelease tablets cii. Meperidine hcl, injection, solution, 10 mg1ml, intravenous, cantrell drug. Meperidine hydrochloride oral solution drug summary. A meperidine overdose can be fatal, especially in a child or other person using the medicine without a prescription. This document has been prepared in accordance with standards for workplace safety, which. Do not forcefully open a nitromist bottle, do not have the container buying online demerol meperidine hcl after use, and do not spray directly toward flames. Meperidine mimics the actions of endogenous neuropeptides via opioid receptors such as the muopioid receptor, thereby producing characteristic morphinelike effects including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence.
Additional training may be required for proper storage of this product special precautions no special precautions required for hazard control. Meperidine hydrochloride information, side effects, warnings. Name of drug classification alternate names narcotic. Dbl pethidine hydrochloride injection bp is a sterile, clear solution. Clinically, it is indicated for the relief of moderate to severe pain, for preoperative medication, for.
Imitrex tablets are contraindicated order demerol meperidine hcl patients with uncontrolled hypertension. The withdrawal symptoms appear more rapidly than with. For additional copies of the printed patient information leaflet medication guide, go to. Meperidine hydrochloride crm safety data sheet section 2. Meperidine hydrochloride overdose occurs when someone takes more than the normal or recommended amount of this medicine. Meperidine hydrochloride is a white crystalline substance with a. Meperidine mimics the actions of endogenous neuropeptides via opioid receptors, thereby producing the characteristic morphinelike effects on the muopioid receptor, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence. May be habit forming description meperidine hydrochloride, is a white crystalline substance with a melting point of 186c to 189c.
Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, bluecolored skin or lips, fainting, or coma. Meperidine hydrochloride pharmacokinetics absorption bioavailability. Greece oel twa 10 ppm 25 mgm3 belgium oel twa hungary oel twa 25 mgm3 10 ppm 25 mgm3 version. Meperidine hydrochloride oral solution and tablets drug. Read the medication guide provided by your pharmacist before you start taking meperidine and each time you get a refill.
Demerol meperidine hydrochloride injection, solution 3 container label, or the product insert. It is readily soluble in water and has a neutral reaction and a slightly bitter taste. Chemically meperidine hydrochloride is 1methyl4phenyl4piperidinecarboxylic acid, ethyl ester, hydrochloride, a white crystalline substance with a melting point of 186c to 189c. Meperidine hydrochloride injection solution meperidine. Wash spillages into an effluent treatment plant or proceed as follows. Patients should be advised that meperidine hydrochloride tablets may impair mental andor physical ability required for the performance of potentially hazardous tasks e. Solutions of meperidine hydrochloride were diluted in dextrose 5% and normal saline to 0.
Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. In the us, meperidine hydrochloride is a schedule ii controlled substance. Meperidine hydrochloride injection usp page 6 of 32 like all opioids, meperidine hydrochloride injection usp is a potential drug of abuse and misuse, which can lead to overdose and death. Meperidine hydrochloride is the hydrochloride salt of a synthetic piperidine ester with opioid analgesic activity. Meperidine hydrochloride monograph for professionals. Demerol meperidine hydrochloride injection, usp rx only. Meperidine hydrochloride is a drug that increases narcotic effects which is a kind of pain medication. Prevent entry into sewers, water courses, basements or confined areas. Meperidine hydrochloride tablets usp meperidine hydrochloride. Section 1 chemical product and company identification.
Pdf chemical stability of meperidine hydrochloride in. Hazardous ingredients present at less than 1% may include sodium hydroxide andor hydrochloric acid which are added for ph adjustment. Meperidine is less effective orally than on parenteral administration. Analgesic, adjunct to anesthesia controlled substance schedule ii pregnancy risk category c action binds to and depresses opiate receptors in spinal cord and cns, altering perception of and response to pain availability injection. Meperidine hydrochloride is a prescription painkiller.
Undergoes extensive firstpass metabolism in the liver, with approximately 5060% of a dose reaching systemic circulation unchanged. Jun 03, 2019 meperidine hydrochloride pharmacokinetics absorption bioavailability. Meperidine hydrochloride oral solution drug information, side. Prolonged use may lead to dependence of the morphine type. Accidental release measures contain spill and collect, as appropriate. Meperidine hydrochloride cii, usp is a synthetic opioid analgesic. Meperidine injection may harm or cause death to other people who use your medication, especially children. Meperidine is a synthetic opioid which has been used widely for therapy of moderatetosevere pain. If you using meperidine injection regularly during your pregnancy, your baby may experience lifethreatening withdrawal symptoms after birth. Conforms to hazcom 2012united states safety data sheet. Meperidine can produce drug dependence of the morphine type and therefore has the potential for being abused. Meperidine hydrochloride is a narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Dbl pethidine hydrochloride injection bp is available as a 50 mg1 ml, 75 mg1.
Meperidine hydrochloride information, side effects. Page 17 safety data sheet according to 19072006ec, article 31 printing date 05. Empirical formula hill notation c 15 h 21 no 2 hcl. Pethidine, also known as meperidine and sold under the brand name demerol among others, is a synthetic opioid pain medication of the phenylpiperidine class. Meperidine has a risk for abuse and addiction, which can lead to overdose and death.
Meperidine hydrochloride injection, usp is a solution containing meperidine hydrochloride, a narcotic analgesic which produces analgesia and sedation. Psychic dependence, physical dependence, and tolerance may develop upon repeated administration of meperidine, and it should be prescribed and administered with the same degree of caution appropriate to the use of morphine. Accidental release measures stop leak if without risk. Meperidine hydrochloride c15h22clno2 cid 5750 structure, chemical names, physical and chemical properties, classification, patents, literature, biological. Apr 18, 2020 concomitant use of meperidine hydrochloride tablets or oral solution with a cyp3a4 inhibitor, such as macrolide antibiotics e. Demerol meperidine hydrochloride injection, solution. Therefore, meperidine hydrochloride injection usp should be prescribed and handled with caution. Mechanism of action of meperidine acts as agonist at specific opioid receptors in the cns to produce analgesia, euphoria, sedation. Ensure that medical personnel are aware of the materials involved and take precautions to protect themselves. The dose of meperidine hydrochloride should be proportionately reduced usually by 25 to 50 percent when administered concomitantly with phenothiazines and many other tranquilizers since they. The dose of meperidine hydrochloride should be proportionately reduced usually by 25 to 50 percent when administered concomitantly with phenothiazines and many other tranquilizers since they potentiate the action of meperidine hcl. This product is a dea controlled substance schedule ii drug and does require dea registration by the customer and completion of dea purchase notification forms. Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle.
Meperidine hydrochloride injection, usp cii for use with pca hospira inc. Bioavailability increases to approximately 8090% in patients with hepatic impairment. Meperidine hydrochloride tablets, usp c epic pharma. Identification of the substancemixture and of the companyundertaking product name. Its molecular formula is c 15 h 21 no 2 hcl, and it has the following chemical structure. Meperidine hydrochloride pethidine hydrochloride sigma. Germany trgs 900 twas 10 ppm 25 mgm3 australia twa germany dfg mak 10 ppm 25 mgm3 10 ppm 25 mgm3 version. Material safety data sheet diphenhydramine hydrochloride, 99. Synthesized in 1938 as a potential anticholinergic agent by the german chemist otto eisleb, its analgesic properties were first recognized by otto schaumann while working for ig farben, germany. Meperidine may also cause severe, possibly fatal, breathing problems. Product name dbl pethidine hydrochloride injection bp 50 mgml. Meperidine hydrochloride oral solution drug information.
If dose is less effective after a few if dose is less effective after a few weeks, do not increase dose without consulting health care professional. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. Meperidine has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury. Meperidine hydrochloride is a narcotic analgesic with multiple actions qualitatively similar to those of morphine. Dailymed demerol meperidine hydrochloride injection, solution. Dailymed meperidine hydrochloride tablet meperidine. Hcl component approximate percent by weight cas number rtecs number meperidine hydrochloride 1 505 ns5950000 nonhazardous ingredients include water for injection. Meperidine hydrochloride pethidine hydrochloride sigmaaldrich.
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